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Endocrine 7 min read Undergraduate & Postgraduate

Hyperosmolar Hyperglycaemic State: Exam Recognition and Management

Differentiate HHS from DKA and focus on profound dehydration, hyperosmolality, slower correction and precipitating illness.

Exam-oriented educational summary · Updated 10 September 2026

Typical exam stem

An older patient with type 2 diabetes presents with severe dehydration, confusion and very high glucose but minimal ketones. How would you manage the case?

Active exam mode

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1. Sixty-second answer plan

1:00

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2. Section checklist

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3. Exam-pearl flashcards

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4. Viva drill

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Question 1 of 30 confident

How does HHS differ from DKA?

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1

Distinguish HHS from DKA

HHS is dominated by marked hyperglycaemia, hyperosmolality and severe dehydration, usually with little or no significant ketoacidosis. Patients are often older and may have substantial comorbidity. Neurological dysfunction becomes more likely as effective osmolality rises.

Mixed DKA/HHS presentations occur, so assess ketones and acid-base status rather than forcing the patient into a single label.

2

Assessment priorities

  • Assess airway, breathing, circulation and mental state.
  • Measure glucose, electrolytes, renal function, ketones and venous blood gas.
  • Calculate or monitor serum osmolality using the local protocol.
  • Search for infection, myocardial infarction, stroke, medication-related causes or reduced access to fluids.
  • Assess thrombosis risk because severe dehydration and hyperosmolality increase risk.
3

Treatment logic

Fluid replacement is central and is usually more gradual than in DKA because rapid shifts in osmolality can be harmful. Insulin is introduced according to the biochemical response and local protocol, particularly when glucose does not fall adequately with fluid or when significant ketosis coexists. Monitor sodium, potassium, glucose, osmolality, renal function and fluid balance closely.

The patient may require high-dependency care when there is marked hyperosmolality, severe electrolyte disturbance, haemodynamic instability, altered consciousness or major comorbidity.

Guideline source for further reading

This page is an original exam-revision summary. For clinical decisions, use current local protocols and the primary guidance below.

Educational use: This material is designed for examination revision and does not replace patient-specific clinical judgement, local treatment protocols or specialist advice.