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Acute Medicine 8 min read Undergraduate & Postgraduate

Sepsis and Septic Shock: The First-Hour Exam Framework

A structured approach to infection-associated organ dysfunction, cultures, antibiotics, fluids, lactate and vasopressor escalation.

Exam-oriented educational summary · Updated 10 September 2026

Typical exam stem

A patient with pneumonia becomes hypotensive, confused and oliguric. How would you assess and manage possible septic shock?

Active exam mode

Plan the case before reading, then mark sections, reveal pearls and self-rate the viva.

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1. Sixty-second answer plan

1:00

Before reading the notes, say or write your assessment, investigations and management structure.

2. Section checklist

Mark each section only after you can explain its main decision points without reading.

3. Exam-pearl flashcards

Try to predict the pearl before revealing it.

4. Viva drill

Answer aloud before rating yourself. Anything marked “review” stays visible in your progress.

Question 1 of 30 confident

How do sepsis and septic shock differ?

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1

Recognise organ dysfunction, not fever alone

Sepsis is life-threatening organ dysfunction caused by a dysregulated response to infection. The exam answer should identify the source of infection, show evidence of organ dysfunction and begin resuscitation immediately. Fever may be absent, especially in older or immunocompromised patients.

2

Immediate assessment

  • Airway and oxygenation, respiratory rate and work of breathing.
  • Blood pressure, pulse, perfusion, mental state and urine output.
  • Serum lactate when available as a marker of illness severity and perfusion abnormality.
  • Blood cultures before antibiotics when this does not meaningfully delay antimicrobial treatment.
  • Source-directed samples and imaging according to the suspected infection.
3

Early treatment

Give appropriate empiric antimicrobials promptly, tailored to the likely source, local resistance patterns, prior colonisation and immune status. Give intravenous crystalloid for hypoperfusion while repeatedly assessing response and avoiding fluid overload. Persistent hypotension despite appropriate fluid resuscitation requires vasopressor support, with norepinephrine commonly used as first-line therapy.

Source control is fundamental. Drain infected collections, remove infected devices or obtain surgical control when required rather than relying on antibiotics alone.

Guideline source for further reading

This page is an original exam-revision summary. For clinical decisions, use current local protocols and the primary guidance below.

Educational use: This material is designed for examination revision and does not replace patient-specific clinical judgement, local treatment protocols or specialist advice.